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ICD-10 Coding for Elevated Parathyroid Hormone(E21.0, E21.1)

Complete ICD-10-CM coding and documentation guide for Elevated Parathyroid Hormone. Includes clinical validation requirements, documentation requirements, and coding pitfalls.

Also known as:

Elevated PTHHyperparathyroidism

Related ICD-10 Code Ranges

Complete code families applicable to Elevated Parathyroid Hormone

E21.0-E21.4Primary Range

Hyperparathyroidism and other disorders of parathyroid gland

This range includes primary, secondary, and tertiary hyperparathyroidism, which are the main conditions associated with elevated parathyroid hormone levels.

Code Comparison: When to Use Each Code

Compare key differences between these codes to ensure accurate selection

CodeDescriptionWhen to UseKey Documentation
E21.0Primary hyperparathyroidismUse when hypercalcemia and elevated PTH are confirmed with imaging or lab tests indicating parathyroid adenoma or hyperplasia.
  • Serum calcium >10.5 mg/dL on 2+ tests
  • Intact PTH >65 pg/mL
  • 24h urine calcium >250 mg (women) / >300 mg (men)
E21.1Secondary hyperparathyroidism, not elsewhere classifiedUse when secondary causes such as vitamin D deficiency are documented.
  • Normal/low calcium + elevated PTH
  • Confirmed vitamin D deficiency (25-OH-D <20 ng/mL)

Clinical Decision Support

Always review the patient's clinical documentation thoroughly. When in doubt, choose the more specific code and ensure documentation supports it.

Key Information: ICD-10 code for elevated parathyroid hormone

Essential facts and insights about Elevated Parathyroid Hormone

The ICD-10 code for primary hyperparathyroidism is E21.0, while secondary hyperparathyroidism not elsewhere classified is E21.1.

Primary ICD-10-CM Codes for elevated parathyroid hormone

Primary hyperparathyroidism
Billable Code

Decision Criteria

clinical Criteria

  • Presence of parathyroid adenoma confirmed by imaging.

Applicable To

  • Parathyroid adenoma
  • Parathyroid hyperplasia

Excludes

  • Familial hypocalciuric hypercalcemia (E83.52)
  • Ectopic hyperparathyroidism (E34.2)

Clinical Validation Requirements

  • Serum calcium >10.5 mg/dL on 2+ tests
  • Intact PTH >65 pg/mL
  • 24h urine calcium >250 mg (women) / >300 mg (men)

Code-Specific Risks

  • Misclassification if imaging/lab results are not documented.

Coding Notes

  • Ensure imaging and lab results are documented to support the diagnosis.

Ancillary Codes

Additional codes that should be used in conjunction with the main diagnosis codes when applicable.

Hypercalcemia

E83.51
Use alongside E21.0 to indicate hypercalcemia as a symptom.

Vitamin D deficiency

E55.0
Use to specify the cause of secondary hyperparathyroidism.

Differential Codes

Alternative codes to consider when ruling out similar conditions to the primary diagnosis.

Familial hypocalciuric hypercalcemia

E83.52
Low urine calcium and genetic testing for CaSR mutation.

Secondary hyperparathyroidism of renal origin

N25.81
Presence of chronic kidney disease.

Documentation & Coding Risks

Avoid these common documentation and coding issues when documenting Elevated Parathyroid Hormone to ensure proper reimbursement, maintain compliance, and reduce audit risk. These guidelines are particularly important when using ICD-10 code E21.0.

Impact

Clinical: May lead to inappropriate treatment plans., Regulatory: Non-compliance with coding standards., Financial: Potential for denied claims.

Mitigation Strategy

Ensure documentation includes specific type and cause., Use decision trees for code selection.

Impact

Reimbursement: May lead to reduced reimbursement rates., Compliance: Non-compliance with coding guidelines., Data Quality: Decreases accuracy of health records.

Mitigation Strategy

Ensure documentation specifies the type of hyperparathyroidism.

Impact

High risk of audit if unspecified codes are used without justification.

Mitigation Strategy

Ensure documentation clearly specifies the type of hyperparathyroidism.

Documentation errors, coding pitfalls, and audit risks are interconnected aspects of medical coding and billing. Addressing all three areas helps ensure accurate coding, optimal reimbursement, and regulatory compliance.

Frequently Asked Questions

Common questions about ICD-10 coding for Elevated Parathyroid Hormone, with expert answers to help guide accurate code selection and documentation.

Documentation Templates for Elevated Parathyroid Hormone

Use these documentation templates to ensure complete and accurate documentation for Elevated Parathyroid Hormone. These templates include all required elements for proper coding and billing.

Primary Hyperparathyroidism Diagnosis

Specialty: Endocrinology

Required Elements

  • Serum calcium levels
  • Intact PTH levels
  • Imaging results

Example Documentation

Patient with persistent hypercalcemia (12.1 mg/dL), elevated intact PTH (180 pg/mL), and 24h urine calcium 350 mg. Sestamibi scan confirms left inferior parathyroid adenoma. Diagnosis: Primary hyperparathyroidism (E21.0).

Examples: Poor vs. Good Documentation

Poor Documentation Example
PTH elevated, monitor calcium.
Good Documentation Example
Intact PTH 145 pg/mL (ref 15-65), serum calcium 11.4 mg/dL on two occasions, 24h urine calcium 320 mg. No renal insufficiency. Diagnosis: Primary hyperparathyroidism (E21.0).
Explanation
The good example provides specific lab results and a clear diagnosis, supporting the code selection.

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