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ICD-10 Coding for Increased Liver Enzymes(R74.01, K71.2)

Complete ICD-10-CM coding and documentation guide for Increased Liver Enzymes. Includes clinical validation requirements, documentation requirements, and coding pitfalls.

Also known as:

Elevated Liver TransaminasesHigh Liver Enzymes

Related ICD-10 Code Ranges

Complete code families applicable to Increased Liver Enzymes

R74-R75Primary Range

Abnormal serum enzyme levels

This range includes codes for abnormal liver function tests, specifically elevated liver enzymes.

Toxic liver disease

This range includes codes for liver damage due to toxins or drugs, which can cause elevated liver enzymes.

Other liver diseases

This range includes codes for conditions like fatty liver, which can be associated with elevated liver enzymes.

Code Comparison: When to Use Each Code

Compare key differences between these codes to ensure accurate selection

CodeDescriptionWhen to UseKey Documentation
R74.01Elevated liver transaminasesUse when liver enzymes are elevated without a confirmed cause.
  • ALT/AST levels ≥1.5x ULN
  • Exclusion of acute hepatitis or toxicity
K71.2Toxic liver disease with acute hepatitisUse when liver enzyme elevation is linked to a specific drug or toxin.
  • Documented causative agent
  • Temporal relationship with drug/toxin exposure

Clinical Decision Support

Always review the patient's clinical documentation thoroughly. When in doubt, choose the more specific code and ensure documentation supports it.

Key Information: ICD-10 code for increased liver enzymes

Essential facts and insights about Increased Liver Enzymes

The ICD-10 code for increased liver enzymes is R74.01, used when liver transaminases are elevated without a known cause.

Primary ICD-10-CM Codes for increased liver enzymes

Elevated liver transaminases
Billable Code

Decision Criteria

clinical Criteria

  • ALT/AST levels elevated without clear etiology

coding Criteria

  • No other specific liver condition identified

Applicable To

  • Elevated ALT
  • Elevated AST

Excludes

  • Toxic liver disease (K71.-)
  • Fatty liver (K76.0)

Clinical Validation Requirements

  • ALT/AST levels ≥1.5x ULN
  • Exclusion of acute hepatitis or toxicity

Code-Specific Risks

  • Misuse when a specific cause is identified
  • Incorrect sequencing as a primary diagnosis

Coding Notes

  • R74.01 should not be used as a primary diagnosis when a specific cause is identified.

Ancillary Codes

Additional codes that should be used in conjunction with the main diagnosis codes when applicable.

Toxic liver disease with acute hepatitis

K71.2
Use when liver enzyme elevation is due to a known toxin or drug.

Adverse effect of other nonopioid analgesics

T39.8x5A
Use for adverse effects related to specific drugs causing liver damage.

Differential Codes

Alternative codes to consider when ruling out similar conditions to the primary diagnosis.

Other abnormal serum enzyme levels

R74.8
Use R74.8 for non-liver specific enzyme elevations.

Fatty liver, not elsewhere classified

K76.0
Use K76.0 for non-toxic causes of liver enzyme elevation.

Documentation & Coding Risks

Avoid these common documentation and coding issues when documenting Increased Liver Enzymes to ensure proper reimbursement, maintain compliance, and reduce audit risk. These guidelines are particularly important when using ICD-10 code R74.01.

Impact

Clinical: Lack of specificity can hinder diagnosis., Regulatory: Non-compliance with documentation standards., Financial: Potential for claim denials.

Mitigation Strategy

Use specific enzyme names (ALT, AST) in documentation., Provide context for enzyme elevation.

Impact

Reimbursement: Incorrect sequencing can lead to denied claims., Compliance: Non-compliance with coding guidelines., Data Quality: Inaccurate clinical data representation.

Mitigation Strategy

Sequence the specific cause as the primary diagnosis and R74.01 as secondary.

Impact

Using R74.01 as a primary code when a specific cause is known.

Mitigation Strategy

Ensure proper sequencing with the specific cause as primary.

Documentation errors, coding pitfalls, and audit risks are interconnected aspects of medical coding and billing. Addressing all three areas helps ensure accurate coding, optimal reimbursement, and regulatory compliance.

Frequently Asked Questions

Common questions about ICD-10 coding for Increased Liver Enzymes, with expert answers to help guide accurate code selection and documentation.

Documentation Templates for Increased Liver Enzymes

Use these documentation templates to ensure complete and accurate documentation for Increased Liver Enzymes. These templates include all required elements for proper coding and billing.

Non-alcoholic steatohepatitis with elevated liver enzymes

Specialty: Gastroenterology

Required Elements

  • Patient history
  • BMI and metabolic indicators
  • Liver enzyme levels
  • Exclusion of other liver diseases

Example Documentation

Patient with BMI 34, ALT 78 U/L, AST 65 U/L, FibroScan CAP 298 dB/m, negative viral hepatitis tests.

Examples: Poor vs. Good Documentation

Poor Documentation Example
Elevated enzymes, likely from meds.
Good Documentation Example
Duloxetine started 4/15/25; ALT increased from 22 to 148 U/L by 5/1/25. Discontinued 5/2/25 with plan to monitor.
Explanation
The good example provides specific drug information, temporal relationship, and a clear plan.

Need help with ICD-10 coding for Increased Liver Enzymes? Ask your questions below.

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