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ICD-10 Coding for Lymphoblastic Leukemia(C91.00, C91.01, C91.02)

Complete ICD-10-CM coding and documentation guide for Lymphoblastic Leukemia. Includes clinical validation requirements, documentation requirements, and coding pitfalls.

Also known as:

Acute Lymphoblastic LeukemiaALL

Related ICD-10 Code Ranges

Complete code families applicable to Lymphoblastic Leukemia

C91.0-C91.02Primary Range

Acute lymphoblastic leukemia codes

This range covers all stages of acute lymphoblastic leukemia, including remission and relapse.

Code Comparison: When to Use Each Code

Compare key differences between these codes to ensure accurate selection

CodeDescriptionWhen to UseKey Documentation
C91.00Acute lymphoblastic leukemia not having achieved remissionUse when the patient has not achieved remission post-treatment.
  • Bone marrow biopsy showing ≥20% blasts
  • Failed induction therapy
  • Persistent lymphoblasts
C91.01Acute lymphoblastic leukemia, in remissionUse when the patient is in complete remission.
  • No detectable blasts on flow cytometry
  • Complete hematologic remission
C91.02Acute lymphoblastic leukemia, in relapseUse when the patient experiences a relapse.
  • Relapse confirmed by bone marrow biopsy
  • Reappearance of CD19+/CD10+ blasts

Clinical Decision Support

Always review the patient's clinical documentation thoroughly. When in doubt, choose the more specific code and ensure documentation supports it.

Key Information: ICD-10 code for acute lymphoblastic leukemia

Essential facts and insights about Lymphoblastic Leukemia

The ICD-10 code for acute lymphoblastic leukemia is C91.0, with specific codes for remission status.

Primary ICD-10-CM Codes for lymphoblastic leukemia

Acute lymphoblastic leukemia not having achieved remission
Billable Code

Decision Criteria

clinical Criteria

  • Presence of ≥20% blasts in bone marrow

Applicable To

  • T-cell precursor leukemia
  • B-cell precursor leukemia

Excludes

  • Chronic lymphocytic leukemia (C91.1)
  • Acute myeloid leukemia (C92.0)

Clinical Validation Requirements

  • Bone marrow biopsy showing ≥20% blasts
  • Failed induction therapy
  • Persistent lymphoblasts

Code-Specific Risks

  • Misclassification if remission status is not clearly documented.

Coding Notes

  • Ensure documentation specifies 'not in remission' status.

Ancillary Codes

Additional codes that should be used in conjunction with the main diagnosis codes when applicable.

Encounter for antineoplastic immunotherapy

Z51.12
Use when the patient is receiving immunotherapy.

Anemia

D64.9
Use if anemia is present as a complication.

Neutropenia

D70.0
Use if neutropenia is present as a complication.

Differential Codes

Alternative codes to consider when ruling out similar conditions to the primary diagnosis.

Chronic lymphocytic leukemia

C91.1
Chronic lymphocytic leukemia is characterized by a slower progression and different cellular markers.

Acute lymphoblastic leukemia, in relapse

C91.02
Relapse is indicated by the reappearance of blasts or other clinical indicators of disease activity.

Acute myeloid leukemia

C92.0
AML is characterized by different cellular morphology and genetic markers.

Documentation & Coding Risks

Avoid these common documentation and coding issues when documenting Lymphoblastic Leukemia to ensure proper reimbursement, maintain compliance, and reduce audit risk. These guidelines are particularly important when using ICD-10 code C91.00.

Impact

Clinical: Incomplete clinical picture., Regulatory: Potential non-compliance with coding standards., Financial: Possible denial of claims.

Mitigation Strategy

Ensure genetic markers are documented in the patient's record., Review lab reports for genetic findings.

Impact

Reimbursement: Incorrect coding can lead to improper reimbursement., Compliance: Non-compliance with coding guidelines., Data Quality: Inaccurate clinical data representation.

Mitigation Strategy

Query for specific remission status: not achieved, in remission, or in relapse.

Impact

Inadequate documentation of remission status can lead to audit issues.

Mitigation Strategy

Implement regular documentation audits and training for clinical staff.

Documentation errors, coding pitfalls, and audit risks are interconnected aspects of medical coding and billing. Addressing all three areas helps ensure accurate coding, optimal reimbursement, and regulatory compliance.

Frequently Asked Questions

Common questions about ICD-10 coding for Lymphoblastic Leukemia, with expert answers to help guide accurate code selection and documentation.

Documentation Templates for Lymphoblastic Leukemia

Use these documentation templates to ensure complete and accurate documentation for Lymphoblastic Leukemia. These templates include all required elements for proper coding and billing.

Initial Diagnosis of ALL

Specialty: Oncology

Required Elements

  • Diagnosis confirmation
  • Remission status
  • Genetic markers

Example Documentation

Patient diagnosed with B-cell ALL, not in remission, with ETV6::RUNX1 fusion.

Examples: Poor vs. Good Documentation

Poor Documentation Example
ALL, stable.
Good Documentation Example
B-cell ALL (C91.01) in remission since 03/2025, MRD-negative via flow cytometry (02/2025), no extramedullary disease.
Explanation
The good example provides specific remission status and supporting clinical data.

Need help with ICD-10 coding for Lymphoblastic Leukemia? Ask your questions below.

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