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ICD-10 Coding for Myelodysplastic Syndromes(D46.9, D46.1, D46.2)

Complete ICD-10-CM coding and documentation guide for Myelodysplastic Syndromes. Includes clinical validation requirements, documentation requirements, and coding pitfalls.

Also known as:

MDSPreleukemia

Related ICD-10 Code Ranges

Complete code families applicable to Myelodysplastic Syndromes

D46.0-D46.ZPrimary Range

Myelodysplastic syndromes

This range covers all subtypes of myelodysplastic syndromes, including unspecified and specific variants.

Code Comparison: When to Use Each Code

Compare key differences between these codes to ensure accurate selection

CodeDescriptionWhen to UseKey Documentation
D46.9Myelodysplastic syndrome, unspecifiedUse when MDS is diagnosed but specific subtype details are not available.
  • Diagnosis of MDS without specific subtype characterization
  • Lack of genetic or cytogenetic testing results
D46.1Refractory anemia with ring sideroblastsUse when bone marrow biopsy confirms ≥15% ring sideroblasts.
  • Bone marrow report showing ≥15% ring sideroblasts
  • Anemia unresponsive to therapy
D46.2Refractory anemia with excess blastsUse when bone marrow biopsy shows 5-19% blasts.
  • Blast percentage (5-9% for RAEB-1; 10-19% for RAEB-2) in bone marrow

Clinical Decision Support

Always review the patient's clinical documentation thoroughly. When in doubt, choose the more specific code and ensure documentation supports it.

Key Information: ICD-10 code for myelodysplastic syndrome

Essential facts and insights about Myelodysplastic Syndromes

The ICD-10 code for unspecified myelodysplastic syndrome is D46.9, with specific subtypes like D46.1 for refractory anemia with ring sideroblasts.

Primary ICD-10-CM Codes for myelodysplasia syndrome

Myelodysplastic syndrome, unspecified
Billable Code

Decision Criteria

clinical Criteria

  • Diagnosis of MDS without specific subtype characterization

coding Criteria

  • No specific genetic or cytogenetic testing results available

Applicable To

  • Myelodysplastic syndrome NOS

Excludes

  • Acute myeloid leukemia (C92.0-)

Clinical Validation Requirements

  • Diagnosis of MDS without specific subtype characterization
  • Lack of genetic or cytogenetic testing results

Code-Specific Risks

  • Overuse of unspecified code when more specific information is available.

Coding Notes

  • Ensure documentation supports the use of an unspecified code by confirming the absence of specific subtype details.

Ancillary Codes

Additional codes that should be used in conjunction with the main diagnosis codes when applicable.

Other specified diseases of blood and blood-forming organs

D75.8
Use for chronic anemia associated with MDS if it impacts care.

Other chronic pancytopenia

R31.29
Use for transfusion-dependent cases.

Personal history of leukemia

Z85.6
Use if MDS transforms to AML.

Differential Codes

Alternative codes to consider when ruling out similar conditions to the primary diagnosis.

Acute myeloid leukemia

C92.0
Presence of ≥20% blasts in bone marrow or peripheral blood.

Sideroblastic anemia

D64.0
Presence of ring sideroblasts without the context of MDS.

Documentation & Coding Risks

Avoid these common documentation and coding issues when documenting Myelodysplastic Syndromes to ensure proper reimbursement, maintain compliance, and reduce audit risk. These guidelines are particularly important when using ICD-10 code D46.9.

Impact

Clinical: May lead to inappropriate treatment decisions., Regulatory: Non-compliance with coding guidelines., Financial: Potential for reduced reimbursement.

Mitigation Strategy

Ensure all diagnostic tests are documented., Regularly update the patient's medical record with new findings.

Impact

Reimbursement: Potential for reduced reimbursement due to lack of specificity., Compliance: Non-compliance with coding guidelines requiring specificity., Data Quality: Decreased data quality and accuracy in patient records.

Mitigation Strategy

Ensure documentation supports the use of specific codes by including subtype details.

Impact

Risk of audits due to use of unspecified codes when specific information is available.

Mitigation Strategy

Ensure documentation supports the use of specific codes.

Documentation errors, coding pitfalls, and audit risks are interconnected aspects of medical coding and billing. Addressing all three areas helps ensure accurate coding, optimal reimbursement, and regulatory compliance.

Frequently Asked Questions

Common questions about ICD-10 coding for Myelodysplastic Syndromes, with expert answers to help guide accurate code selection and documentation.

Documentation Templates for Myelodysplastic Syndromes

Use these documentation templates to ensure complete and accurate documentation for Myelodysplastic Syndromes. These templates include all required elements for proper coding and billing.

Hematology Progress Note

Specialty: Hematology

Required Elements

  • Assessment and plan for MDS
  • Lab results including CBC and bone marrow biopsy
  • Treatment plan and follow-up

Example Documentation

Assessment: Myelodysplastic syndrome, RAEB-2 (D46.22) - 12% blasts on 3/25/25 marrow aspirate - Complex karyotype: -7, +8 - Transfusion-dependent anemia (Hgb 7.2 g/dL baseline) Plan: Initiate azacitidine per NCCN guidelines - Monitor for AML transformation q3mo

Examples: Poor vs. Good Documentation

Poor Documentation Example
MDS, stable
Good Documentation Example
MDS-RS-SLD (D46.1), SF3B1 mutation VAF 38%, Hgb 8.4 g/dL requiring biweekly PRBC transfusions
Explanation
The good example provides specific subtype details and current management, supporting accurate coding.

Need help with ICD-10 coding for Myelodysplastic Syndromes? Ask your questions below.

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