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ICD-10 Coding for Myelofibrosis(D47.4, D75.81)

Complete ICD-10-CM coding and documentation guide for Myelofibrosis. Includes clinical validation requirements, documentation requirements, and coding pitfalls.

Also known as:

Primary MyelofibrosisChronic Idiopathic MyelofibrosisPost-Polycythemia Vera MyelofibrosisPost-Essential Thrombocythemia Myelofibrosis

Related ICD-10 Code Ranges

Complete code families applicable to Myelofibrosis

D47.4Primary Range

Chronic myeloproliferative disease

Primary code for chronic idiopathic myelofibrosis and secondary myelofibrosis in myeloproliferative diseases.

Other specified diseases of blood and blood-forming organs

Used for secondary myelofibrosis, such as post-polycythemia vera or post-essential thrombocythemia.

Code Comparison: When to Use Each Code

Compare key differences between these codes to ensure accurate selection

CodeDescriptionWhen to UseKey Documentation
D47.4Chronic myeloproliferative diseaseUse for primary myelofibrosis with documented bone marrow findings and mutation status.
  • Bone marrow biopsy showing megakaryocyte proliferation and reticulin fibrosis
  • JAK2, CALR, or MPL mutation status
D75.81Other specified diseases of blood and blood-forming organsUse for secondary myelofibrosis with documentation of the underlying condition.
  • Documentation of underlying condition such as post-PV or post-ET

Clinical Decision Support

Always review the patient's clinical documentation thoroughly. When in doubt, choose the more specific code and ensure documentation supports it.

Key Information: ICD-10 code for primary myelofibrosis

Essential facts and insights about Myelofibrosis

The ICD-10 code for primary myelofibrosis is D47.4, used for chronic idiopathic myelofibrosis with documented bone marrow findings.

Primary ICD-10-CM Codes for myelofibrosis

Chronic myeloproliferative disease
Billable Code

Decision Criteria

clinical Criteria

  • Presence of JAK2, CALR, or MPL mutations

documentation Criteria

  • Bone marrow biopsy results

Applicable To

  • Chronic idiopathic myelofibrosis
  • Primary myelofibrosis

Excludes

  • Secondary myelofibrosis (D75.81)

Clinical Validation Requirements

  • Bone marrow biopsy showing megakaryocyte proliferation and reticulin fibrosis
  • JAK2, CALR, or MPL mutation status

Code-Specific Risks

  • Misclassification if secondary myelofibrosis is not distinguished

Coding Notes

  • Ensure documentation specifies primary versus secondary myelofibrosis.

Ancillary Codes

Additional codes that should be used in conjunction with the main diagnosis codes when applicable.

Splenomegaly, not elsewhere classified

R16.1
Use if splenomegaly is symptomatic.

Anemia in neoplastic disease

D63.0
Use if anemia requires separate treatment.

Differential Codes

Alternative codes to consider when ruling out similar conditions to the primary diagnosis.

Other specified diseases of blood and blood-forming organs

D75.81
Used for secondary myelofibrosis, such as post-PV or post-ET.

Chronic myeloproliferative disease

D47.4
Used for primary myelofibrosis.

Documentation & Coding Risks

Avoid these common documentation and coding issues when documenting Myelofibrosis to ensure proper reimbursement, maintain compliance, and reduce audit risk. These guidelines are particularly important when using ICD-10 code D47.4.

Impact

Clinical: Inaccurate diagnosis and treatment planning., Regulatory: Non-compliance with coding standards., Financial: Potential for claim denials.

Mitigation Strategy

Ensure mutation testing is documented, Include mutation status in clinical notes

Impact

Reimbursement: Incorrect DRG assignment leading to lower reimbursement., Compliance: Non-compliance with coding guidelines., Data Quality: Inaccurate clinical data representation.

Mitigation Strategy

Do not code D63.0 unless anemia requires separate treatment.

Impact

Incorrect selection of principal diagnosis can lead to audit issues.

Mitigation Strategy

Verify documentation supports the principal diagnosis choice.

Documentation errors, coding pitfalls, and audit risks are interconnected aspects of medical coding and billing. Addressing all three areas helps ensure accurate coding, optimal reimbursement, and regulatory compliance.

Frequently Asked Questions

Common questions about ICD-10 coding for Myelofibrosis, with expert answers to help guide accurate code selection and documentation.

Documentation Templates for Myelofibrosis

Use these documentation templates to ensure complete and accurate documentation for Myelofibrosis. These templates include all required elements for proper coding and billing.

Hematology consult for myelofibrosis

Specialty: Hematology

Required Elements

  • JAK2, CALR, MPL mutation status
  • Bone marrow biopsy results
  • Splenomegaly documentation

Example Documentation

ASSESSMENT: Primary myelofibrosis confirmed by JAK2 V617F mutation and bone marrow biopsy showing reticulin fibrosis grade 3.

Examples: Poor vs. Good Documentation

Poor Documentation Example
Myelofibrosis, needs transfusion
Good Documentation Example
Post-ET myelofibrosis (D75.81) with CALR type 1 mutation; transfusion-dependent anemia (Hgb 7.2 on 2/2025); spleen palpable 10 cm below LCM
Explanation
The good example provides specific mutation status and detailed clinical findings, supporting accurate coding.

Need help with ICD-10 coding for Myelofibrosis? Ask your questions below.

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