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ICD-10 Coding for Prolactinoma(D35.2, E22.1)

Complete ICD-10-CM coding and documentation guide for Prolactinoma. Includes clinical validation requirements, documentation requirements, and coding pitfalls.

Also known as:

Pituitary adenomaHyperprolactinemia tumor

Related ICD-10 Code Ranges

Complete code families applicable to Prolactinoma

D35-D36Primary Range

Benign neoplasms

This range includes benign neoplasms of the pituitary gland, which is where prolactinomas are classified.

Disorders of other endocrine glands

This range includes endocrine disorders such as hyperprolactinemia, which is often associated with prolactinomas.

Code Comparison: When to Use Each Code

Compare key differences between these codes to ensure accurate selection

CodeDescriptionWhen to UseKey Documentation
D35.2Benign neoplasm of pituitary glandUse when a benign tumor of the pituitary gland is confirmed by imaging.
  • MRI or CT imaging confirming pituitary tumor
  • Prolactin levels >200 µg/L
E22.1HyperprolactinemiaUse when elevated prolactin levels are documented and associated with a pituitary tumor.
  • Serum prolactin level >200 µg/L
  • Symptoms of hormone excess such as galactorrhea

Clinical Decision Support

Always review the patient's clinical documentation thoroughly. When in doubt, choose the more specific code and ensure documentation supports it.

Key Information: What is the ICD-10 code for prolactinoma?

Essential facts and insights about Prolactinoma

The ICD-10 code for prolactinoma is D35.2. Use E22.1 for associated hyperprolactinemia.

Primary ICD-10-CM Codes for prolactinoma

Benign neoplasm of pituitary gland
Billable Code

Decision Criteria

clinical Criteria

  • Presence of pituitary tumor on imaging

documentation Criteria

  • Prolactin level >200 µg/L

Applicable To

  • Pituitary adenoma
  • Prolactinoma

Excludes

  • Malignant neoplasm of pituitary gland (C75.1)

Clinical Validation Requirements

  • MRI or CT imaging confirming pituitary tumor
  • Prolactin levels >200 µg/L

Code-Specific Risks

  • Misclassification with other pituitary tumors
  • Omitting documentation of tumor size

Coding Notes

  • Ensure imaging and prolactin levels are documented to support diagnosis.

Ancillary Codes

Additional codes that should be used in conjunction with the main diagnosis codes when applicable.

Hyperprolactinemia

E22.1
Use when prolactinoma causes elevated prolactin levels.

Differential Codes

Alternative codes to consider when ruling out similar conditions to the primary diagnosis.

Malignant neoplasm of pituitary gland

C75.1
Confirmed malignancy through biopsy or histological examination.

Drug-induced hyperprolactinemia

E22.0
Elevated prolactin due to medication use.

Documentation & Coding Risks

Avoid these common documentation and coding issues when documenting Prolactinoma to ensure proper reimbursement, maintain compliance, and reduce audit risk. These guidelines are particularly important when using ICD-10 code D35.2.

Impact

Clinical: Inadequate assessment of tumor impact., Regulatory: Non-compliance with documentation standards., Financial: Potential for incorrect DRG assignment.

Mitigation Strategy

Use templates prompting for tumor size., Educate staff on documentation standards.

Impact

Reimbursement: Incorrect coding may lead to denied claims., Compliance: Non-compliance with coding guidelines., Data Quality: Inaccurate clinical data representation.

Mitigation Strategy

Always pair E22.1 with D35.2 when a tumor is confirmed.

Impact

Missing prolactin levels or imaging results.

Mitigation Strategy

Implement documentation checklists.

Documentation errors, coding pitfalls, and audit risks are interconnected aspects of medical coding and billing. Addressing all three areas helps ensure accurate coding, optimal reimbursement, and regulatory compliance.

Frequently Asked Questions

Common questions about ICD-10 coding for Prolactinoma, with expert answers to help guide accurate code selection and documentation.

Documentation Templates for Prolactinoma

Use these documentation templates to ensure complete and accurate documentation for Prolactinoma. These templates include all required elements for proper coding and billing.

Prolactinoma diagnosis and management

Specialty: Endocrinology

Required Elements

  • Tumor size
  • Prolactin levels
  • Symptoms
  • Treatment response

Example Documentation

Assessment: Prolactinoma status post transsphenoidal resection. Current prolactin: 18 ng/mL. MRI: No residual tumor.

Examples: Poor vs. Good Documentation

Poor Documentation Example
Pituitary tumor noted.
Good Documentation Example
MRI-confirmed pituitary macroadenoma (2.5 cm) with serum prolactin 348 ng/mL.
Explanation
The good example provides specific imaging and lab results, supporting the diagnosis.

Need help with ICD-10 coding for Prolactinoma? Ask your questions below.

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